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As quantum computing advances, the threat it poses to classical cryptographic algorithms becomes increasingly urgent. This practical guide explores how to protect sensitive data in transit and at rest using post-quantum cryptography (PQC). It begins by explaining the unique power of quantum computers and why they jeopardize widely used cipher algorithms such as RSA and ECC. The guide then examines practical strategies to safeguard Transport Layer Security (TLS), Internet Key Exchange (IKE), and data encryption keys against quantum-enabled adversaries. By presenting viable PQC options and hybrid approaches, this resource helps security professionals prepare for a post-quantum future while maintaining backward compatibility and resilience during the transition.